Research Perspectives - Tools for Visualisation of Portfolios
EPSRC logo

EPSRC Database


Source RCUK EPSRC Data

EP/I033959/1 - Diels-Alder/Ene Reactions for the Multi-Component Synthesis of Natural Product Inspired Bioactive Chemical Libraries

Research Perspectives grant details from EPSRC portfolio

http://www.researchperspectives.org/gow.grants/grant_EPI0339591.png

Dr MJ Hall EP/I033959/1 - Diels-Alder/Ene Reactions for the Multi-Component Synthesis of Natural Product Inspired Bioactive Chemical Libraries

Principal Investigator - School of Chemistry, Newcastle University

Scheme

First Grant Scheme

Research Areas

Chemical Biology and Biological Chemistry Chemical Biology and Biological Chemistry

Chemical Reaction Dynamics and Mechanisms Chemical Reaction Dynamics and Mechanisms

Computational & Theoretical Chemistry Computational & Theoretical Chemistry

Collaborators

Demuris Ltd Demuris Ltd

Start Date

08/2011

End Date

08/2013

Value

£98,914

Similar Grants

Automatic generation of similar EPSRC grants

Similar Topics

Topic similar to the description of this grant

Grant Description

Summary and Description of the grant

Despite the many fantastic advances in health treatment over the past 50 years new drug molecules are always needed. Sometimes this is to combat existing health problems for which a solution is yet to be found, such as some cancers, and sometimes this is to deal with emerging problems, such as the rise of drug resistant bacteria (e.g. MRSA). Modern drug discovery relies on chemists to make new molecules for testing as potential drugs which can be then optimised to for use by a patient. However current approaches to this problem can be very time consuming and inefficient. The inefficiency of these processes also results in the creation of large quantities of chemical waste which can in turn cause environmental problems. This project aims to find a solution to this through the use of one-pot chemical reactions where, in place of sequential chemical transformations (one after the other), several can happen in the same reaction flask. This efficient approach leads to a vast reduction in the waste generated, whilst at the same time increases the number of different molecules a chemist can make in a day and thus the number of molecules which can be tested. Making many molecules, rapidly and with a reduction in waste can only help to speed up the drug discovery process.Specifically this project will develop new one-pot methods to make a library of very different molecules, very quickly. The molecules we will target have the potential to be new anticancer or new antibacterial agents, so will also test these molecules as lead compounds for treatment of these diseases.

Structured Data / Microdata


Grant Event Details:
Name: Diels-Alder/Ene Reactions for the Multi-Component Synthesis of Natural Product Inspired Bioactive Chemical Libraries - EP/I033959/1
Start Date: 2011-08-03T00:00:00+00:00
End Date: 2013-08-02T00:00:00+00:00

Organization: Newcastle University

Description: Despite the many fantastic advances in health treatment over the past 50 years new drug molecules are always needed. Sometimes this is to combat existing health problems for which a solution is yet to be found, such as some cancers, and sometimes this is t ...