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EP/G048444/1 - Micro-Plasma Technology for Controlling Cellular Interactions on Medical Implants

Research Perspectives grant details from EPSRC portfolio

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Professor JW Bradley EP/G048444/1 - Micro-Plasma Technology for Controlling Cellular Interactions on Medical Implants

Principal Investigator - Electrical Engineering and Electronics, University of Liverpool

Other Investigators

Dr CM Sheridan, Co InvestigatorDr CM Sheridan

Professor P Weightman, Co InvestigatorProfessor P Weightman

Dr R Williams, Co InvestigatorDr R Williams

Scheme

Standard Research

Research Areas

Biophysics and soft matter physics Biophysics and soft matter physics

Plasma and Lasers Plasma and Lasers

Surface Science Surface Science

Collaborators

Mawson Institute Mawson Institute

Hiden Analytical Ltd Hiden Analytical Ltd

Start Date

09/2009

End Date

05/2013

Value

£581,062

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Grant Description

Summary and Description of the grant

Plasma discharges are an ideal tool to modify polymeric surfaces used in biomedical research, introducing specific elements or functional groups onto the surface. In particular, plasma processes can transfer cell-adhesive or cell-repulsive groups over small domains, often through the use of masks.One major aim of this study will be to develop new atmospheric pressure plasmas (micro-plasma jets) as platforms to create chemically defined bio-surfaces on the micron scale without the need for masks. Atmospheric pressure plasmas have the advantage over vacuum-based techniques in that the plasmas themselves can be scaled to a size approaching cellular dimensions, offering novel applications in medicine and biology, and are cheap, portable and very efficient in terms of power consumption. The micro-plasma jets will operate in number of different gases and polymerisable monomers and chemical features with specific functionality down to 50 microns dimensions will be defined on a range of polymeric surfaces. The technology will be directly applied to the surface modification of intraocular lens IOL implants to study and control the interaction of human epithelial cells (LEC) on the lens. The adhesion, proliferation and migration of LECs on chemically defined surfaces and gradients will be of prime importance in assessing the technology as a tool for bio-materials engineering. The chemical and physical nature of the polymerized surfaces (analysed using XPS and other surface analytical tools) will be correlated to measurements of the plasma jet composition and also the cell-surface interactions.

Structured Data / Microdata


Grant Event Details:
Name: Micro-Plasma Technology for Controlling Cellular Interactions on Medical Implants - EP/G048444/1
Start Date: 2009-09-01T00:00:00+00:00
End Date: 2013-05-31T00:00:00+00:00

Organization: University of Liverpool

Description: Plasma discharges are an ideal tool to modify polymeric surfaces used in biomedical research, introducing specific elements or functional groups onto the surface. In particular, plasma processes can transfer cell-adhesive or cell-repulsive groups over smal ...