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EP/G013160/1 - Quantifying the Interplay of Structure and Reactivity in Ring Closing and Cross Metathesis

Research Perspectives grant details from EPSRC portfolio

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Professor JM Percy EP/G013160/1 - Quantifying the Interplay of Structure and Reactivity in Ring Closing and Cross Metathesis

Principal Investigator - Pure and Applied Chemistry, University of Strathclyde

Scheme

Standard Research

Research Areas

Chemical Reaction Dynamics and Mechanisms Chemical Reaction Dynamics and Mechanisms

Computational & Theoretical Chemistry Computational & Theoretical Chemistry

Synthetic Organic Chemistry Synthetic Organic Chemistry

Related Grants

EP/G013020/1

Start Date

07/2009

End Date

07/2012

Value

£256,115

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Grant Description

Summary and Description of the grant

The proposed programme will use a number of synthetically accessible systems to improve our quantitative understanding of the organic reaction mechanism of the alkene ring closing methathesis (RCM) and cross metathesis (CM) reactions. We wish to determine effective molarities (EMs) as a function of ring size n and substitution patterns, to measure absolute cyclisation and oligomerisation rates, and to use computational methods to understand these data. The programme will develop expertise and tools in physical organic chemistry (experimental kinetics, computational methods) while investigating a reaction of considerable fundamental importance and acute current relevance. We propose to use computational and experimental kinetic techniques synergistically to refine and/or challenge fundamental and general ideas about aspects of the mechanism of RCM reactions, bringing the reaction within the domain of expertise of POC. We also wish to develop complementary insight concerning cross metathesis (CM) reactions, insights which are required if we are to understand the issues surrounding cyclisation efficiency fully. The successful delivery of this programme will advance research knowledge significantly and make a considerable contribution to UK standing in the important and topical field of alkene metathesis chemistry.

Structured Data / Microdata


Grant Event Details:
Name: Quantifying the Interplay of Structure and Reactivity in Ring Closing and Cross Metathesis - EP/G013160/1
Start Date: 2009-07-21T00:00:00+00:00
End Date: 2012-07-20T00:00:00+00:00

Organization: University of Strathclyde

Description: The proposed programme will use a number of synthetically accessible systems to improve our quantitative understanding of the organic reaction mechanism of the alkene ring closing methathesis (RCM) and cross metathesis (CM) reactions. We wish to determine ...