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EP/G009546/1 - Signal Amplification in MR achieved through novel inorganic templates

Research Perspectives grant details from EPSRC portfolio

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Professor S Duckett EP/G009546/1 - Signal Amplification in MR achieved through novel inorganic templates

Principal Investigator - Chemistry, University of York

Other Investigators

Professor GGR Green, Co InvestigatorProfessor GGR Green

Scheme

Standard Research

Research Areas

Analytical Science Analytical Science

Chemical Biology and Biological Chemistry Chemical Biology and Biological Chemistry

Computational & Theoretical Chemistry Computational & Theoretical Chemistry

Collaborators

Bruker Bruker

Start Date

01/2009

End Date

07/2012

Value

£668,449

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Grant Description

Summary and Description of the grant

Nuclear magnetic resonance (NMR) is arguably one of the most important methods for characterising materials in solution. It relies on the fact that certain nuclei possess the property of magnetism. Consequently when they are placed in a uniform magnetic field a precise amount of energy is required to change their magnetic orientation and this is exploited to inform on their local physical and chemical environment. The most widely recognised use of this phenomenon is found the clinical application of Magnetic Resonance Imaging (MRI) which offers unparalleled non-invasive insights into the state and health of the body. In normal conditions the behaviour of nuclei in a magnetic field creates one of the major drawbacks of both NMR and MRI : poor sensitivity. This lack of sensitivity arises because the distribution of magnetic orientations in a sample is such that the effects of only a very few of the molecules can be observed as a signal. Hyperpolarisation, the subject of this proposal, is a method for altering the magnetic distribution so that the observed signal can be increased by several orders of magnitude. Until recently effective hyperpolarisation could be achieved either by a lengthy and small scale process of transferring magnetisation from electrons to nuclei, or by using a hydrogenation reaction to transfer magnetisation from hyperpolarised nuclei in parahydrogen. Parahydrogen constitutes one quarter of naturally occurring hydrogen at room temperature and is the fuel of the space shuttle. This proposal is concerned with a new technique that allows hyperpolarisation of a substance without the need for a chemical reaction. The proposal is specifically concerned with the optimisation of the process, in terms of the chemistry of catalysis, the range of molecules that can interact with the hyperpolarised catalysts and the physical basis of the phenomenon. The proposal seeks to create a flow cell for generic use for the continuous production of hyperpolarised substances in large quantities. It is predicted that the provision of this unprecedented new method for increasing signal strengths could have wide ranging applications within chemistry and also have important implications for methods that seek to improve MRI and therefore its power as a diagnostic tool.

Structured Data / Microdata


Grant Event Details:
Name: Signal Amplification in MR achieved through novel inorganic templates - EP/G009546/1
Start Date: 2009-01-08T00:00:00+00:00
End Date: 2012-07-07T00:00:00+00:00

Organization: University of York

Description: Nuclear magnetic resonance (NMR) is arguably one of the most important methods for characterising materials in solution. It relies on the fact that certain nuclei possess the property of magnetism. Consequently when they are placed in a uniform magnetic fi ...